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Development and Evaluation of Polyherbal Formulation for Anti Diabe... |
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by Biological Sciences |
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ABSTRACT |
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Diabetes is the most common metabolic disorder that |
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involves various pathogenic mechanisms and is |
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characterized by high blood sugar levels. Genetic and |
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environmental factors cause insufficient insulin |
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secretion, increased glucose production, abnormal fat, or |
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protein metabolism. Major sources of diabetes are chronic |
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complications that started with prolonged hyperglycemia. |
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According to ayurvedic scriptures such as Charak Samhita, |
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polyherbal formulations have been mentioned to have anti- |
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diabetic potentials. Thus, the present study was aimed to |
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find the anti-diabetic effect of polyherbal formulation |
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in rat models. Diabetes was induced by a single dose of |
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Streptozotocin (60 mg/kg) for 72 hours. The effect of the |
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polyherbal formulation was studied in diabetic rats for |
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21 days. The biochemical and anti-oxidant parameters such |
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as fasting blood glucose, cholesterol, triglycerides, |
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HDL, LDL, VLDL, SGOT, SGPT, Urea, Uric acid, LPO, SOD, |
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and GSH were measured during the study. The polyherbal |
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formulation produced a significant reduction of fasting |
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blood glucose and lipid profile. Kidney function tests, |
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liver function tests, and anti-oxidant parameters were |
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also improved. Overall, after 21 days of study, the |
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results show that the polyherbal formulation is much more |
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effective for type 1 diabetes in rats. |
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Date Published: 2022-02-17 21:56:04 |
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Identifier: barti-h-et-al.-2021-2 |
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Item Size: 5473111 |
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Language: eng |
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Media Type: texts |
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# Topics |
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Diabetes |
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Insulin |
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Polyherbal formulation |
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Lipid Profile |
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Anti-oxidant |
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@ir_research_publication |
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