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DTIC ADB136689: Detoxication of Mycotoxins and Other Toxins and Com... |
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by Defense Technical Information Center |
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This research, was initially concerned with detoxication |
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of certain trichothecene toxins, and has recently changed |
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its emphasis and is now directed toward the cyanoginosin |
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toxins. Studies on the tricothecenes have been brought to |
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a conclusion. A newly recognized naturally occurring |
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glutathione derivative Gamma-glutamyl glutathione) has |
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been prepared and methods for large scale preparation of |
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this compound are being developed. Other glutathione |
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derivatives that may be useful in detoxication are also |
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under study. Cyanoginosin toxin, supplied to us by the |
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Army, has been identified as of the LR type. Structural |
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features of this toxin have been investigated and its |
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toxicity has been studied after chemical modification. |
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Preliminary studies indicate that the dehydropeptide |
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moiety of the cyanoginosin LR toxin is essential for |
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toxicity. This is an interesting point because |
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dehydropeptides undergo facile reaction with certain SH- |
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containing molecules. The possible role of glutathione in |
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the modification of toxicity due to cyanoginosin peptides |
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is currently being explored. Keywords: Liver, Kidney, L-2- |
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Oxothiazolidine-4-carboxylate, Cyanoginosin, Microcystin, |
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Glutathione monoethyl ester. |
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Date Published: 2018-01-16 16:50:28 |
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Identifier: DTIC_ADB136689 |
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Item Size: 15860871 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Meister, Alton; CORNELL... |
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