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DTIC ADA611001: Prenatal Antidepressants and Autism Spectrum Disorder |
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by Defense Technical Information Center |
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According to the CDC Autism Spectrum Disorder (ASD) |
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prevalence has risen to 1/66, but its causes remains |
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unclear. Croen et al. (2011) reported an increase in ASD |
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in children whose mother s took SSRI antidepressants |
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(ADs) during pregnancy. We are testing this hypothesis in |
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rodents. The study is a 2-year long experiment to be |
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decoded and analyzed in YR02. Groups treated during |
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gestation and lactation are: saline (SAL), citalopram |
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(CIT), fluoxetine (FLX), bupropion (DUP), and a newly |
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added positive control group given valproic acid (VPA) on |
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E12 only. There will be 20 litters/group (except CIT10 |
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with 10) for a total of 110 litters (x8 |
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offspring/litter=880 progeny). All ADs caused unexpected |
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skin irritation which is being successfully treated with |
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a 1.5% topical lidocaine spray. Current number of sperm- |
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positive females enrolled: SAL=12, CIT10=10, CIT5=11, |
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FLX5=11, BUP15=12, and VPA500=10; total=66 litters (528 |
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offspring), leaving 44 more litters yet to be enrolled. |
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Litters completed: SAL=6, CIT10=5, CIT5=4, FLX=6, BUP=6, |
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and VPA500=3; total=30, leaving 80 litters still in |
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testing or yet to be enrolled (totally 640 progeny). |
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Given the current rate of enrollment, the last litter is |
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to be enrolled in February 2015 and the last litter to |
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finish testing by the end of March 2015. |
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Date Published: 2018-09-27 00:57:11 |
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Identifier: DTIC_ADA611001 |
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Item Size: 9558189 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; ; CHILDREN'S HOSPITAL M... |
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