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DTIC ADA598467: Disease Heterogeneity and Immune Biomarkers in Prec... |
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by Defense Technical Information Center |
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Ovarian epithelial tumors are highly diverse and the |
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exact tissue of origin is still unclear. Although the |
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ovarian surface epithelial cells (OSEs) are believed to |
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be the originating site, more recent evidence suggests |
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that the ovarian tumors could instead arise directly from |
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extraovarian tissues that are embryologically derived |
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from the m llerian ducts. Using genetically engineered |
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mice (Cre-loxP) with conditional mutations in the Kras |
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and PI3K/Pten pathways (KrasPten mice), we demonstrated |
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in year one that activation of these oncogenic pathways |
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in the peritoneal cavity, may lead to ovarian tumors that |
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are histomorphologically identical to those arising in |
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mice with Kras and PI3K pathways activated in the OSE |
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only. Further validation of these novel findings via |
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expression profiling is currently in progress. If |
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confirmed, our work may lead to identification of a new |
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paradigm in ovarian tumorigenesis, one that may not |
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require the involvement of the OSE. We also identified |
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for the first time that activation of the Kras and PI3K |
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pathways in the uterine lining leads to endometrial |
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hyperplasia, a premalignant condition, predisposing to |
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endometrial adenocarcinoma. This animal model would |
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provide unparalleled opportunities for studies on |
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premalignant and malignant lesions of the female genital |
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tract, with secondary ovarian involvement. |
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Date Published: 2018-09-19 14:53:11 |
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Identifier: DTIC_ADA598467 |
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Item Size: 22540216 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; ; MAGEE WOMENS HEALTH C... |
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