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DTIC ADA591994: Biomarkers of Renal Tumor Burden and Progression in...
by Defense Technical Information Center
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Renal lesions occur commonly in people with TSC and can
cause significant morbidity and mortality [1]. Although
most solid renal lesions of TSC are benign angiomyolipoma
(AML), some are in fact cancerous. Moreover, rapidly
growing AMLs can be life threatening when abnormal blood
vessels rupture [2]. Based on the hypothesis that renal
tumor growth is associated with measurable changes in
urine composition and on the knowledge that angiogenesis
is essential for tumor expansion [3, 4], we have
predicted that factors associated with angiogenesis and
with renal injury will increase during periods of TSC-
associated renal tumor growth. We are testing this
candidate driven approach to identify factors in urine or
serum that reflect renal tumor burden and whose
concentrations change as tumors grow. This project can be
described in two aims. (A) Monitor the progression of TSC
renal disease by combining prospective data collection
with retrospective chart review of a large population of
TSC patients with respect to gender, age, patient size,
TSC genotype, renal lesions (e.g. lesion number,
appearance and growth rates) and renal function
parameters (e.g. blood pressure, serum chemistries,
urinalysis and urine chemistries). (B) Measure soluble
growth factors, angiogenesis factors and renal injury
molecules in urine and serum samples from patients with
TSC and evaluate these candidates as surrogate markers of
renal tumor burden and growth.
Date Published: 2018-09-17 03:30:03
Identifier: DTIC_ADA591994
Item Size: 11125035
Language: english
Media Type: texts
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