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DTIC ADA567855: Characterization of the Pathological and Biochemica...
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The role of Project 1 in this Program Project is: 1. To
preserve tissue from 72 brains, according to a
standardized protocol for neuropathological studies
(project # 1) and for morphometric studies (project# 2);
2. To implement clinical and neuropathological exclusion
criteria to reduce the risk of distortion of results and
conclusions by comorbidity, pre-, peri, and postmortem
tissue changes, (3) to define type, topography and
severity of qualitative developmental alterations in
idiopathic autism and autism associated with dup15, and
(4) to examine correlations between focal developmental
changes and epilepsy and sudden death. Severe
microcephaly, with brain weight reduced by 300 g is one
of the most significant signs of global encephalopathy
increasing the risk of epilepsy in dup 15 cohort. 2.8
times more frequent developmental alterations, especially
common in the hippocampal formation of autistic subjects
with dup15, and presence up to 11 different types of
developmental alterations are the major contributors to
early onset of epilepsy and high risk of SUDEP. Reduced
volume of neurons in a majority of subcortical structures
and some cortical regions in the brain of autistic
children with known and unknown etiology indicates that
altered trajectory of neuron growth and desynchronization
of neuronal development is a common denominator for
autism regardless of etiology and is linked to autistic
phenotype and intellectual deficits. However, different
pattern of developmental deficits neuron volume in
idiopathic autism (most severe volume deficit in 4-8
years old subjects and correction of neuron size in late
childhood) than in autism associated with dup (15)
(permanent neuron volume deficit regardless of age)
indicates that etiology defines the trajectory of neuron
and brain development.
Date Published: 2018-09-04 11:22:22
Identifier: DTIC_ADA567855
Item Size: 51794028
Language: english
Media Type: texts
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