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DTIC ADA507006: Developmental and Environmental Regulation of AaeIA... |
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by Defense Technical Information Center |
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Apoptosis (programmed cell death) is a tightly regulated |
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physiological process. The inhibitors of apoptosis |
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proteins (IAPs) are key regulators for apoptosis. An |
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inhibitor of apoptosis protein gene IAP1 was recently |
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cloned from Aedes aegypti (L.) (AaeIAP1, GenBank |
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accession no. DQ993355); however, it is not clear whether |
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AaeIAP1 is developmentally and environmentally regulated. |
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In this study, we applied quantitative polymerase chain |
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reaction (PCR) to investigate the expression levels of |
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the AaeIAP1 transcript in different developmental stages |
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and under different environmental conditions. Our results |
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revealed that the expression of the AaeIAP1 transcript |
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was detectable in all life stages of Ae. aegypti, with |
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significantly higher levels in pupal and adult stages |
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than in larval stages. Furthermore, when Ae. aegypti was |
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exposed to all stressful environmental conditions (e.g., |
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low and high temperatures, UV radiation, acetone, and |
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permethrin insecticide treatment), the expression level |
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of AaeIAP1 transcript was increased significantly. Our |
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results suggest that AaeIAP1 might play an important role |
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in both the physiological development of Ae. aegypti and |
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stress-induced apoptosis. |
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Date Published: 2018-07-23 16:30:56 |
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Identifier: DTIC_ADA507006 |
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Item Size: 8819398 |
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Language: english |
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Media Type: texts |
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