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DTIC ADA506648: Solidago Virgaurea for Prostate Cancer Therapy |
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by Defense Technical Information Center |
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Prostate cancer is one of the most resistant tumors to |
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chemotherapy among all adenocarcinomas, and there is |
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virtually no effective therapeutic regimen available for |
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this cancer. Hormonal treatment is the most effective |
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therapy in advanced cancer, however, almost all the |
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patients who undergo hormonal therapy inevitably develop |
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hormone-resistant tumors. Therefore, developing a better |
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therapeutic agent by targeting a specific gene or pathway |
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with well-defined clinical rationale is needed. We chose |
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a target called Fatty acid synthase (FAS) because we |
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found that FAS is strongly expressed in prostate cancer |
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cells but not in normal cells and that inhibiting the FAS |
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expression causes specific tumor cell death. In this |
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project, we plan to test the hypothesis that an active |
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component of Solidago virgaurea specifically inhibits the |
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FAS activity and induces apoptosis in prostate tumor |
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cells. Our specific aims are (i) to elucidate the |
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molecular mechanism of growth inhibitory effect of S. |
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virgaurea by defining the signal pathway and factors |
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responsible for apoptosis, and (ii) to examine the effect |
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of the active component of Solidago virgaurea on |
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tumorigenesis in an animal model. |
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Date Published: 2018-07-23 16:40:51 |
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Identifier: DTIC_ADA506648 |
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Item Size: 116008260 |
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Language: english |
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Media Type: texts |
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