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DTIC ADA469963: Population Based Assessment of MHC Class I Antigens...
by Defense Technical Information Center
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Despite advances in chemotherapy and radiation therapies,
advanced breast cancer still carries a high mortality
rate. The need for effective therapies is urgent. The
overall aim of this research proposal is to recognize
early markers of disease and their interaction with other
epidemiological risk factors that can serve as risk
indicators for subsequent development of breast cancer
from precancerous lesions, and as prognostic markers for
progression from primary to metastatic disease. The major
histocompatibility complex (MHC) class I molecules are
found on the cell membrane of all cells in the body and
are involved in intercellular communications and in
complex interactions with the immune system. Cancer cells
with reduced or aberrant MHC molecules have been shown to
evade immune surveillance and become selected for cancer
progression and spread of disease to distant sites of the
body. About half of all breast cancers have complete loss
or reduced level of MHC class I molecules and this
finding has been associated with increased tumor
invasiveness and more aggressive cancers with poorer
outcome. The outlined studies are expected to better
define the clinical significance of abnormal MHC class I
molecules in precancerous and invasive breast lesions as
markers of immunological events that could affect
survival, selection, and outgrowth of precancerous cells,
and their subsequent progression to breast cancer. These
MHC losses could also mark more aggressive tumors and
thus contribute to selection of appropriate treatments in
individual cases.
Date Published: 2018-06-13 04:55:06
Identifier: DTIC_ADA469963
Item Size: 25510160
Language: english
Media Type: texts
# Topics
DTIC Archive; Worsham, Maria J ; HENR...
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