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DTIC ADA463301: AR-NcoR Interaction as a Therapeutic Target for Pro... |
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by Defense Technical Information Center |
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Aim 1 is to determine the precise molecular basis for |
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NCoR binding to the RU486 liganded AR. Since the previous |
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report we have used chromatin immunoprecipitation to |
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demonstrate that RU486 enahnces AR NCoR recruitment to AR |
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assembled on androgen regulated genes. We have also |
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generated the additional AR and NCoR mutants to define |
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the precise amino acids mediating the interaction. Aim 2 |
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is to determine whether NCoR recruitment can suppress |
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androgen independent expression of AR regulated genes and |
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prostate cancer growth, and identify molecular markers |
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that predict whether RU486 (or related drugs) will be |
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effective in particular prostate cancers in vivo. We have |
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now used chromatin immunoprecipitation to examine the |
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functional effects of RU486 mediated NCoR recruitment, |
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and find that NCoR is not mediating deacetylation and |
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hence not suppressing gene expression. The reason for |
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this is now under investigation. These results, in |
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conjunction with our previous data, reflect further |
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progress towards determining the structural basis for AR- |
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NCoR interaction (Aim 1) and determining whether this |
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interaction can be exploited to treat prostate cancer |
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(Aim 2). |
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Date Published: 2018-06-09 20:33:48 |
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Identifier: DTIC_ADA463301 |
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Item Size: 11009255 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Balk, Steven P ; BETH I... |
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dticarchive |
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# Uploaded by |
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@chris85 |
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