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DTIC ADA459280: Activation of Alternative Wnt Signaling Pathways in... |
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by Defense Technical Information Center |
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Wnts are lipid-modified secreted glycoproteins that |
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regulate diverse biological processes. I have shown that |
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Wnt5a, which functions in non-canonical Wnt signaling, |
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promoted proliferation, cell survival and network |
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formation on endothelial cells. In new experiments, Wnt5a |
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induced non-canonical Wnt signaling in endothelial cells, |
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as measured by Dishevelled and ERK1/2 phosphorylation, as |
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well as inhibited canonical Wnt signaling. Using shRNA |
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technology to target Wnt5a expression, both endothelial |
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cell network formation and migration were inhibited. A |
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DNA array screening for Wnt5a-regulated genes in cultured |
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cells identified several encoding angiogenic regulators, |
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and Tie-2, a receptor for angiopoietins, was validated as |
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a new target gene of non-canonical Wnt signaling in human |
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endothelial cells. So far, non-canonical Wnt signaling |
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had unknown functions on endothelial cell biology. |
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Experimental findings from this project highlight the |
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importance of non-canonical Wnt signaling on |
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angiogenesis. |
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Date Published: 2018-06-07 20:34:24 |
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Identifier: DTIC_ADA459280 |
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Item Size: 23907660 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Masckauchan, T N ; COL... |
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