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DTIC ADA458306: BRCC36, A Novel Subunit of a BRCA1 E3 Ubiquitin Lig... |
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by Defense Technical Information Center |
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Breast cancer is a genetically heterogeneous disease, and |
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multiple genes remain to be identified among nonBRCA1 and |
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BRCA2 breast cancer-prone families. This statement is |
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supported by the evidences that BRCA1 and BRCA2 mutations |
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are associated with between 20 to 60% of hereditary |
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breast cancer families, which is less than originally |
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estimated, especially in population-based studies. We |
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have taken the approach that the next BRCA genes will be |
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those that encode for proteins whose functions are linked |
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to important cell regulatory pathways. We have recently |
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found one such candidate BRCA3 protein, referred to as |
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BRCC36. We have reported a profound increase in BRCC36 |
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expression in breast tumors. Furthermore, our studies |
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have defined BRCC36 as a direct regulator of BRCA1 |
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activation and nuclear foci formation in response to IR |
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in a number of breast cancer cell lines. Our results |
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suggest that down-regulation of BRCC36 expression impairs |
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the DNA repair pathway activated in response to IR and |
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appears to sensitize breast cancer cells to IR-induced |
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apoptosis. Therefore, it is intriguing to speculate that |
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targeting BRCC36 may aid in the treatment of radiation |
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resistant breast tumors, |
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Date Published: 2018-06-07 20:49:11 |
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Identifier: DTIC_ADA458306 |
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Item Size: 95358068 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Chen, Xiaowei; FOX CHAS... |
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