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DTIC ADA441190: Pharmacologic Modification of the Cellular Energy C... |
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by Defense Technical Information Center |
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Resuscitation from hemorrhagic shock with fluid (Ringer's |
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Lactate) and blood may not correct all of the metabolic |
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abnormalities associated with shock. Patients who are |
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apparently fully resuscitated may yet develop organ |
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failure syndromes such as respiratory failure and renal |
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failure. The objective of our research has been to |
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evaluate the therapeutic efficacy of three |
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pharmacological agents which have been suggested as |
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adjuncts to standard resuscitation (glutamine, crocetin, |
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and dehydroepiandrosterone (DHEA)) by studying their use |
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in a rodent model. The emphasis throughout was to assess |
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the potential of these agents for treating battlefield |
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injuries. Both glutamine and crocetin produced much more |
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rapid recovery of depleted ATP levels after shock and |
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resuscitation, decreased apoptotic mediators and |
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apoptosis itself, and improved survival. DHEA did not |
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improve hemodynamic response in a porcine shock model, |
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nor did it affect ATP or apoptosis. Glutamine and |
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crocetin are good candidates for clinical trials. |
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Date Published: 2018-05-29 02:15:46 |
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Identifier: DTIC_ADA441190 |
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Item Size: 10021071 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Van Way, III, Charles; ... |
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# Uploaded by |
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@chris85 |
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