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DTIC ADA438735: Radiation Protection by the Antioxidant Alpha-Tocop... |
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by Defense Technical Information Center |
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Radiological terrorism and use of nuclear weapons are |
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major concerns for national defense and homeland |
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security. At low doses of radiation, the hazards from |
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these scenarios may not be apparent immediately, but may |
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result in late arising pathologies like cancer and |
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pulmonary fibrosis. At high doses, the hazards vary from |
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incapacitation due to nausea and diarrhea to mortality. |
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Free radical species of oxygen, derived from the |
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interaction of ionizing radiation with critical |
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biological targets and with the aqueous cellular milieu, |
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are implicated in these hazards. Scavengers of free |
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radicals have been shown to be effective protectors from |
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radiation damage. However, many of these protectors are |
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either toxic or cannot be administered orally at doses |
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that are effective. The data presented here indicate that |
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alpha-tocopherol succinate (TS), a free radical |
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scavenger, can be used as a radioprotector with low |
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toxicity. Tocopherol succinate was dispersed in a vehicle |
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containing polyethylene glycol-400 (PEG) and given orally |
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(PO) to male CD2F1 mice. About 22-24 hours later, they |
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were irradiated at different doses of 60Co radiation at a |
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dose rate of 0.6 Gy/min. To maximize the protection, |
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different formulations of the vehicle were used. Mice |
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were monitored for body weight and survival for 30 days. |
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In vitro experiments were done to study the effects of TS |
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on radiation-induced apoptosis of Jurkat cells |
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(lymphoblastoid cell line) using flow cytometry. Although |
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different formulations for solubilizing TS were used, |
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oral formulations based on PEG were found to provide |
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better protection than those based on oil emulsions. The |
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best protection was obtained with a combination of PEG- |
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400 and an emulsifier consisted of benzyl alcohol and |
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ethyl alcohol. |
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Date Published: 2018-05-28 03:27:48 |
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Identifier: DTIC_ADA438735 |
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Item Size: 7778013 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Singh, Vijay K ; ARMED ... |
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