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DTIC ADA426381: Development and Evaluation of a Percutaneous Techni... |
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by Defense Technical Information Center |
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Metastatic lesions in the proximal femur are a common and |
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serious manifestation of breast cancer. These lesions can |
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be painful and can lead to pathological fracture. |
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Prophylactic surgical fixation is advised in patients |
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thought to be at high risk of fracture and typically |
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involves placement of a prosthetic implant or compression |
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hip screw. This study is investigating whether proximal |
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femora with metastatic lesions can be repaired by simply |
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filling the defect with bone cement |
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(polymethylmethacrylate), an innovative procedure that |
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could be performed percutaneously and could eliminate the |
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need for implanting hardware in many cases. If defects |
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could be repaired using this technique, patients would |
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benefit from shorter and less invasive surgical |
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procedures, less pain and discomfort, greatly reduced |
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recovery time, and shorter hospital stays - all at much |
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lower cost. To date, mechanical testing and finite |
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element modeling of femora with and without repaired |
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simulated tumors support the feasibility of this repair |
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technique. The finite element modeling method has been |
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calibrated to produce accurate estimates of measured |
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fracture load and validated on an independent data set. |
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This method is being used to develop clinical guidelines |
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for assessing the need for prophylactic fixation and for |
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using the proposed percutaneous repair procedure. |
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Date Published: 2018-05-21 07:05:45 |
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Identifier: DTIC_ADA426381 |
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Item Size: 12175865 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Keyak, Joyce H ; CALIFO... |
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