Introduction
Introduction Statistics Contact Development Disclaimer Help
DTIC ADA418782: Genetic Polymorphisms, Estrogens, and Breast Density
by Defense Technical Information Center
Thumbnail
Download
Web page
Mammographic density appears to be a strong predictor of
breast cancer risk. Endogenous steroid hormones have been
shown to be important in the development and progression
of breast cancer. Because some metabolites of endogenous
estrogens may have more estrogenic effects than others,
genetically determined differences in biosynthesis and
metabolic pathways of estrogens may affect breast cancer
risk. This study will address the following specific
aims: 1. To examine the relation between the urinary
ratio of 16alpha- hydroxyestrone (16alpha-OHEl) and 2-
hydroxyestrone (OHEl) and polymorphisms in the genes
coding for some hormone metabolizing enzymes. 2.To
investigate differences in urinary excretion of estrone3-
glucuronide, a marker of endogenous estradiol, between
women with variant alleles for polymorphisms in genes
coding for hormone producing (CYP17) and metabolizing
enzymes (COMT, CYP1Al, CYPlA2, and CYP1B1) and women with
the wildtype genotype. 3. To analyze the relation of
mammographic density patterns with the urinary excretion
of estrone-3 glucuronide, the urinary ratio of 16alpha-
OHEl: 2%O-OHEl, and the presence of variant alleles for
hormone producing and metabolizing enzymes. During the
last year, we have completed the recruitment of 316 study
subjects (218 pre- and 98 postruenopausal women). The
subjects represent the population of Hawaii with large
proportions of women from different ethnic groups. The
majority of mammograms has undergone quantitative
mammographic density assessment. Blood for the DNA
analysis and urine samples for the premenopausal women
were collected on cycle day 19. Blood or mouthwash and
urine samples were collected for all women, coded,
processed, and frozen. The genotyping for 7 polymorphisms
using published PCR/RFLP methods has just been completed,
2 more are under way. The urinary analysis will be
finished within the next 2 months.
Date Published: 2018-05-14 23:47:23
Identifier: DTIC_ADA418782
Item Size: 20159521
Language: english
Media Type: texts
# Topics
DTIC Archive; Maskarinec, Gertraud; H...
# Collections
dticarchive
additional_collections
# Uploaded by
@chris85
# Similar Items
View similar items
PHAROS
You are viewing proxied material from tilde.pink. The copyright of proxied material belongs to its original authors. Any comments or complaints in relation to proxied material should be directed to the original authors of the content concerned. Please see the disclaimer for more details.