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DTIC ADA406210: Cellular and Molecular Changes of the Respiratory S... |
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by Defense Technical Information Center |
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The use of ACM in the military and private sector is |
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increasing. Yet little is known concerning the toxicity |
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of the byproducts of ACM combustion. Recently, as a |
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result of accidents and mishaps, significant interest has |
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developed regarding the potential health hazards |
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associated with the combustion of ACM and the release of |
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toxic gases, vapors and particles. We hypothesize that |
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exposure to such atmospheres result in cellular and |
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molecular alterations that ultimately may lead to lung |
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injury. Smoke inhalation is one of a number of conditions |
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that can result in the development of adult respiratory |
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distress syndrome (ARDS), a severe form of lung injury |
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that carries with it significant mortality. We propose to |
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investigate the cellular and molecular changes of the |
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respiratory system in rats exposed to ACM combustion |
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atmospheres. By identifying the critical pathways |
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necessary for the development of lung injury from ACM |
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combustion atmospheres, we could apply that knowledge |
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toward new and improved methods of treatment for lung |
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injury including ARDS. In addition, by investigating the |
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cellular and molecular changes prior to lung injury, we |
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may be able to identify biomarkers that would be early |
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predictors of those individuals at risk for progression |
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to lung injury following exposure. |
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Date Published: 2018-05-08 16:48:53 |
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Identifier: DTIC_ADA406210 |
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Item Size: 5713184 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Reinhart, Paul; NAVAL H... |
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