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	DTIC ADA383020: ETACT - An Innovative Approach to Scintimammography
	by Defense Technical Information Center
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	This project investigates the use of a novel approach to
	scintimammography (SMM) known as emission tuned aperture
	computed tomography (ETACT). In ETACT, a series of
	projections of the radionuclide distribution in the
	breast are acquired with fiducial markers. These data are
	reconstructed into tomographic slices. The hypothesis of
	this project is that ETACT will significantly increase
	the diagnosis accuracy of SMM, and can be applied in a
	simple, flexible and practical manner. We have developed
	a simulation model for the acquisition process of ETACT
	and have used this tool to perform a preliminary
	evaluation of the aperture size appropriate for ETACT. It
	was determined that a 4 mm diameter aperture was optimal
	for ETACT, as currently implemented. We performed a
	preliminary phantom evaluation to compare its performance
	to planar SMM. This evaluation indicated that contrast
	(0.2 vs 0.52) and the SNR (0.54 vs 2.05) were
	substantially higher for ETACT as compared to planar SMM.
	We will continue to work on our ETACT simulator to
	include attenuation and scatter. We will simulate ETACT
	data to evaluate aperture size and projection divergence
	as a function of tumor size, location and: T/NT ratio. We
	will develop a methodology for acquiring ETACT data using
	optical markers. We will acquire phantom data to evaluate
	fiducial placement, tumor size and location, the effect
	of cardiac or liver activity and compare the results to
	SMM. In the third year, we will continue to evaluate
	ETACT and develop an ETACT clinical prototype.

	Date Published: 2018-04-29 22:34:32
	Identifier: DTIC_ADA383020
	Item Size: 30380853
	Language: english
	Media Type: texts

	# Topics
	DTIC Archive; Fahey, Frederic H ; WAK...

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