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DTIC ADA377913: TGFa-myc Interactions in Mammary Tumorigenesis. |
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by Defense Technical Information Center |
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This grant studied the nature of the synergistic |
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interaction of the growth factor TCFa and the nuclear |
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protoonco-protein'product c-Myc for bitransgenic mouse |
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mammary tumorigenesis. We found evidence of a |
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multifactoral interaction of the two genes, involving |
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cooperative stimulation of proliferation, anchorage |
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independent colony formation, suppression of cell death |
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(apoptosis), and chromosomal destabilization. In |
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addition, we observed that the TGFalpha-related growth |
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factors amphiregulin and cripto-l were likely to have |
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tumor promoting effects similar to TGFalpha in breast |
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cancer. Further studies addressed the ability of c-Myc |
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and TGFalpha to interact in a novel paracrine mammary |
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system in vivo. In summary, this grant allowed the |
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development of a new model system whereby the |
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interactions of two important genes in breast cancer may |
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be dissected in vivo at the molecular level. |
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Date Published: 2018-04-28 13:25:06 |
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Identifier: DTIC_ADA377913 |
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Item Size: 439048401 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Dickson, Robert B ; GEO... |
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