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DTIC ADA235894: Genetic Restriction of Protective Immunity to Plasm... |
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by Defense Technical Information Center |
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Ten congenic strains of mice were immunized with |
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irradiated sporozoites of Plasmodium yoelii. When |
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challenged with viable sporozoites, only two strains had |
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a high proportion of animals which did not develop blood- |
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stage infections. Genes both within and outside the H-2 |
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region affected the degree of protection. Immunity did |
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not correlate with anti-sporozoite antibody levels. In |
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vivo depletion of CD8+T cells did not alter immunity in |
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two of three congenic strains, implying the existence of |
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a novel mechanism of cell-mediated immunity. |
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Date Published: 2018-03-02 12:41:33 |
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Identifier: DTIC_ADA235894 |
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Item Size: 7287176 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Weiss, W R ; NAVAL MED... |
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@chris85 |
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