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DTIC ADA206514: Additivity of Retinal Damage for Multiple-Pulse Las...
by Defense Technical Information Center
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This study has examined the cumulative effects of
multiple-pulse laser exposures in contributing to retinal
damage via a thermal mechanism. Three sets of experiments
have been conducted to determine the variation of
multiple- pulse thresholds: With the interval between
pulses; with the number of pulses in the pulse train when
the interpulse interval is held constant; and with the
retinal image size when both number of pulses and
interpulse interval are invariant. In addition, thermal
model calculations were carried out to compare model
predictions with the experimental data. Conclusions from
the experimental data are: (1) The threshold for a
multiple-pulse train is related to that for an individual
pulse in the train by a function of the number of pulses,
but is independent of pulse-repetition frequency and
pulse train length. This observation is in general
accordance both with the thermal model predictions and
with previously empirical models. (2) The additivity of
multiple pulses is quantitatively similar for collimated
and expanded laser beams incident at the eye. (3) The
repair or recovery of laser-induced reversible retinal
damage (i.e. , sub-threshold with respect to the
ophthalmoscopic lesion endpoint) is slow, having a time
constant of the order of days. Thus, the cumulative
nature of multiple-pulse or repeated exposures within a
24-hr period is relatively unaffected by the ongoing
repair process; and only when repeated daily exposures
are of concern does the repair process become a factor.
Keywords: Laser damage; Retina.
Date Published: 2018-02-22 09:39:01
Identifier: DTIC_ADA206514
Item Size: 18388556
Language: english
Media Type: texts
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DTIC Archive; Zuclich, Joseph A ; KRU...
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