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DTIC ADA189029: In Vitro Toxicity Evaluation of Ten Particulate Mat... |
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by Defense Technical Information Center |
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This study was conducted to explore alternative |
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toxicological testing methods for assessing the potential |
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health hazard of particulate materials. The in vitro |
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toxic effect of eight particles (graphite fibers, |
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polycrystalline iron whiskers, aluminum dust, nickel- |
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coated graphite fibers, brass dust, Printex L carbon |
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black, micro-260 synthetic graphite dust and KS-2 natural |
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graphite dust) was evaluated on the upper respiratory |
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epithelium of hamster tracheal organ cultures based on |
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microanatomical and histomorphometric changes. Tissue |
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changes induced by the test articles were compared to |
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changes that occurred in tracheal organ cultures exposed |
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to crocidolite asbestos (positive control) and glass |
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beads (negative control), in addition to untreated |
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explants. The relative toxicity of each test particle was |
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characterized base on qualitative histopathologic and |
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morphometric differences relative to the positive and |
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negative controls. Crocidolite asbestos and Ni-coated |
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graphite were the most reactive in this study. Iron |
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whiskers, aluminum dust, and KS-2 graphite caused an |
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intermediate level of tissue response, while the |
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remaining substances did not cause significant tissue |
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responses compared to control explants. The most |
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cytotoxic materials were brass dust and Ni-coated |
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graphite. |
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Date Published: 2018-02-17 02:27:24 |
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Identifier: DTIC_ADA189029 |
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Item Size: 107270846 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Placke, Michael E ; BAT... |
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