 |
DTIC ADA187300: Effect of Electric Fields on Membrane Bound (Na,K)-... |
 |
by Defense Technical Information Center |
 |
Thumbnail |
|
Download |
 |
Web page |
|
|
|
A protein of a cell membrane is structurally sensitive to |
|
an electric field because of its charges, helix dipoles |
|
and polarizability. When such a protein is exposed to an |
|
applied oscillating electric field, the conformational |
|
oscillation of the protein can be coupled to driving an |
|
endergonic reaction. We have investigated how such an |
|
interaction between the sodium, potassium +(Na,K)-ATPase |
|
of human erythrocytes and an a.c. field leads to active |
|
pumping of K+ and Na against their respective |
|
concentration gradient. Experiments done in this past |
|
year establish that optimum frequency of rubidium Rb+ (an |
|
equivalent of K+) occurs at 1.0 kHz and that for Na+ |
|
efflux at 1 MHz or higher. The optimum voltage for both |
|
pumps is 20 V/cm. An electroconformational coupling model |
|
is proposed and the above data analyzed according to the |
|
model. In the continuation years we will study the |
|
relationship between stimulating voltage and optimum |
|
frequency, and vise versa. Its molecular mechanisms will |
|
be investigated and more quantitative analysis performed. |
|
Keywords: Electrophysiology; Biochemistry. |
|
|
|
Date Published: 2018-02-16 19:18:43 |
|
Identifier: DTIC_ADA187300 |
|
Item Size: 5253285 |
|
Language: english |
|
Media Type: texts |
|
|
|
# Topics |
|
DTIC Archive; Tsong, Tian Y ; JOHNS H... |
|
|
|
# Collections |
|
dticarchive |
|
additional_collections |
|
|
|
# Uploaded by |
|
@chris85 |
|
|
|
# Similar Items |
|
View similar items |
|
|
|
PHAROS |
|
