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DTIC ADA165015: Urinary and Hematological Indices of Hypohydration,
by Defense Technical Information Center
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As part of a large scale field feeding system test we had
the unique opportunity to collect and study hundreds of
overnight urine aliquots which were obtained immediately
prior to a fasting blood sample on days 1, 20, and 44 of
the field test. To evaluate the hydrational status of
test subjects and criteria of hypohydration, urine
aliquots were categorized by specific gravity or = 1.03
(n=124) or 1.03 (n=540). Creatinine levels were elevated
(p.001) in the concentrated urine samples, but a
decreased trend in Na(+)/K(+) ratios in these samples
failed to achieve statistical significance (p=0.1).
However, when individuals with high specific gravity
urine were further subclassified by a criterion of weight
loss 3% from original body weight, then creatinine
concentrations were elevated (p=.05) while Na(+)/K(+)
ratios were decreased (p=.05) when compared with levels
in subjects also with high specific gravity but weight
loss 3%. Serum urea nitrogen/creatinine ratios were
significantly increased (days 1 and 44, p=.02) in test
subjects whose urine samples exceeded 1.03 in specific
gravity. The results of this study indicated that
prodromal hypohydration, indicated by concomitant
elevations in urinary specific gravity and creatinine,
was not reflected in the common indices of circulatory
hypohydration- hematocrit and osmolality. Alternatively,
urea nitrogen/creatinine ratio may be a sensitive
circulatory index of imminent hypohydration.
Date Published: 2018-02-06 05:43:54
Identifier: DTIC_ADA165015
Item Size: 15208083
Language: english
Media Type: texts
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DTIC Archive; Francesconi,R P ; ARMY...
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