 |
DTIC ADA150715: Nonspecific Resistance Induced by an Immunopharmaco... |
 |
by Defense Technical Information Center |
 |
Thumbnail |
|
Download |
 |
Web page |
|
|
|
Treatment of mice with Bordetella pertussis vaccine |
|
resulted in resistance to mouse adenovirus infection. |
|
Antiviral activity was associated with surface components |
|
of B. pertussis. Acellular fractions with antiviral |
|
activity were obtained by relatively gentle extraction |
|
methods, i.e., 1.0 M NaCl extraction or Waring blender |
|
treatment. B. pertussis lipopolysaccharide extracted by |
|
the Westphal procedure possessed antiviral activity. |
|
Lipoplysaccharide complexed with protein appeared to have |
|
more activity than purified lipopolysaccharide. B. |
|
pertussis vaccine did not induce cross-reacting |
|
antibodies with either neutralizing or protective |
|
activity toward mouse adenovirus. Peritoneal exudate |
|
cells obtained from mice treated with B. pertussis |
|
vaccine inhibited vesicular stomatitis virus |
|
multiplication in L-929 cells. Removal of adherent cells |
|
from the peritoneal exudate cell population increased the |
|
antiviral activity toward vesicular stomatitis virus. |
|
Mouse adenovirus migrates from the peritoneum to the |
|
blood within minutes after intraperitoneal inoculation. |
|
Infection with sublethal doses of mouse adenovirus |
|
resulted in a transient splenomegaly. Mice developed |
|
maximal neutralizing antibody titers after infection with |
|
as little as 10 plaque-forming units. Infection with |
|
lethal does of mouse adenovirus resulted in a fever |
|
response (hypothermia) before death. |
|
|
|
Date Published: 2018-01-28 16:22:32 |
|
Identifier: DTIC_ADA150715 |
|
Item Size: 15870557 |
|
Language: english |
|
Media Type: texts |
|
|
|
# Topics |
|
DTIC Archive; Winters,A L ; ALABAMA ... |
|
|
|
# Collections |
|
dticarchive |
|
additional_collections |
|
|
|
# Uploaded by |
|
@chris85 |
|
|
|
# Similar Items |
|
View similar items |
|
|
|
PHAROS |
|
