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DTIC ADA1031362: Physiologic Aspects of Porcine Hemorrhage. III. He... |
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by Defense Technical Information Center |
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Young domestic swine, 6 animals per group, were subjected |
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to 30 and 50% hemorrhage of their estimated blood volume |
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over a 1-hour period while in a conscious recumbent |
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state. Before and for 5 hours after hemorrhage, |
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hemodynamic functions were measured to assess the |
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characteristics of spontaneous recovery from hemorrhagic |
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hypotension. Six additional pigs, treated similarly |
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except for hemorrhage, served as controls. Immediately |
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after 30% hemorrhage, arterial mean, systolic, and |
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diastolic blood pressure were 79, 104, and 59 mm Hg, |
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respectively. During th 5-hour recovery period, these |
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pressures reverted to 105, 129, and 81 mm Hg which were |
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nearly the same as pre-hemorrhage values. Heart rates |
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were unaltered by hemorrhage but increased slightly |
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during recovery. Pulse pressure was not significantly |
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affected by hemorrhage or recovery, while hematocrits |
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declined during and following blood loss. After 50% |
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hemorrhage, arterial mean, systolic, and diastolic |
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pressures were 46, 79, and 26 mm Hg, respectively. During |
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the recovery period these pressures rose to 81, 104, and |
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62 mm Hg; all of these values remained significantly |
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below pre-hemorrhage values. Pulse pressure increased |
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significantly during the recovery period, while |
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hematocrits decreased to an even greater degree than |
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those in the 30% group. In both hemorrhage groups |
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spontaneous recovery was associated with a progressive |
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decrease in hematocrit which reflected a transfer of |
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interstitial fluid to the circulation. |
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Date Published: 2020-03-01 21:35:49 |
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Identifier: DTIC_ADA1031362 |
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Item Size: 18784061 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Hannon,J P ; LETTERMAN... |
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