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DTIC AD1033394: Parathyroid Hormone-Related Peptide (PTHrP) as a Ne... |
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by Defense Technical Information Center |
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The purpose of this study is to investigate the role of |
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parathyroid hormone-related protein (PTHrP) in cancer |
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stem cell-driven triple-negative breast cancer. Our goal |
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is to confirm PTHrP as a targetable molecular driver in |
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order to develop better therapies against this |
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notoriously hard-to-treat family of cancers. We have now |
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constructed animal models with mammary epithelium |
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fluorescent labelled cells to allow tracing of cancer |
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stem cells from the primary mammary tumor to the |
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metastatic site. We will use these models to compare |
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cancer stem cell behavior in PTHrP-ablated and non- |
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ablated animals. Using CRISPr technology, we are |
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developing pre-clinical PTHrP-ablated human triple- |
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negative breast cancer cell lines to test the cancer- |
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blocking efficacy of our anti-PTHrP monoclonal antibodies |
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and identify cell markers associated with cancer |
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progression events. We are using a large tissue bank from |
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triple-negative breast cancer patient tumors to |
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investigate the relationship between triple-negative |
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breast cancer tumoral PTHrP expression levels and cancer |
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recurrence. The goal is also to develop a method to |
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identify patients who would benefit from a novel anti- |
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PTHrP therapy. We have already determined that PTHrP is |
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overexpressed in the tumor tissue of the majority of |
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triple-negative breast cancer cases. |
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Date Published: 2020-03-19 04:47:54 |
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Identifier: DTIC_AD1033394 |
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Item Size: 11032838 |
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Language: english |
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Media Type: texts |
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# Topics |
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DTIC Archive; Kremer,Richard; Researc... |
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