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Evaluation of Antihypertensive Activity of Aqueous-methanol Extract... |
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by Onoja, Emmanuel |
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The present study aimed at evaluating |
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antihypertensive activity of aqueous-methanol extract of |
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Sida ovata on normal saline induced-hypertensive rats. The |
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induced-hypertensive rats were administered 100, 200, 400 |
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and 800 mg/kg doses |
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of extract of S. ovata and their |
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Systolic Blood Pressure (SBP), Diastolic Blood Pressure |
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(DBP), Mean Arterial |
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Blood Pressure (MABP) and Pulse Pressure (PP)) were |
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monitored for four weeks. |
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The SBP which were 121.25, 127.55, 138.25 and 141.50 mmHg |
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for week 1, 2, 3 |
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and 4 respectively were lowered to almost normal by 100 |
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mg/kg for week 1 and |
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800 mg/kg for weeks 2, 3 and 4 respectively. DBP were |
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lowered to almost |
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normal level by 400 mg/kg of the extract except for week |
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4 that utilized 800 |
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mg/kg to achieve similar result. PP required 400 mg/kg to |
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lower it to almost |
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normal except week 1 that achieved similar result with |
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200 mg/kg. While 100 |
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and 400 mg/kg were required to lower the MABP to almost |
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normal level for week |
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1 and 2 respectively, 800 mg/kg was required for weeks 3 |
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and 4. The results |
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showed a dose-dependent decrease in blood pressure. |
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Interestingly, extract of |
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S. ovata demonstrated hypertensive |
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potency, making it a good therapeutic agent for managing |
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blood pressure |
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related diseases. |
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Date Published: 2025-04-26 14:41:17 |
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Identifier: 85433_202504 |
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Item Size: 7423821 |
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Language: eng |
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Media Type: texts |
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# Topics |
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Albino rats; Aqueous-methanol extract... |
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@asian_journal_of_applied_science_and_technology |
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