I believe our understandings - sensemaking - is ultimately based
  upon physical systems but in the "compressed" format the brain
  uses.
  [1]https://en.wikipedia.org/wiki/Where_Mathematics_Comes_From
  covers some of the idea as it relates to mathematics for
  example. As each metaphor lays upon each metaphor, the layers of
  abstraction remove it from its sources because the brain is
  capable of making connections that physical systems don't seem
  to just yet. It allows us to imagine things-not-yet-possible (or
  perhaps not at all) but their basis (going right back to when
  we're babies) I believe stems from there and builds upon it.
  Well yes, the physical systems / body activities that make the
  initial connection from physical system/activity into a
  simplified compressed 'brain' format. A lot of it is buried
  right in our language. Grasping an idea. Grasping a ball with
  your hands. Seems too simple, but it seems to be everywhere

References

  Visible links
  1. https://l.facebook.com/l.php?u=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FWhere_Mathematics_Comes_From&h=kAQHltKmf