Never had the patience to 'get' the Blender UI.* I used to get
  involved in UI flame wars on Usability and computer-human
  interaction forums years ago and when I see Blender's mess (even
  their updated UI, which is definitely an improvement to earlier
  versions), i start thinking of ALL THE WAYS they could improve
  the UI, start reorganizing it in my brain, and then get angry
  that such a powerful and useful program has it's own special UI,
  which would be fine if ... ...ok, I'm starting a rant :P**
  Anyway, that always ends up being a distraction from me learning
  Blender.* It's stupid really.* But I get the reaction when I see
  stupid UI mistakes or tricks or games online too... ok, I'm
  going to settle down now :P Im ok, Im ok I'm ok :P You learned
  it.* It's learnable and there's probably some great benefits to
  the layout.* It strikes me as a primarily "key-stroke"
  interface, so once you learn the keystrokes, you'd good to go.*
  I guess I just don't 'feel like it' and all this rant is just a
  coverup for my own laziness :)