I was a computer technician for a small computer store for about
  11 months last year, and ran across many weird combinations. The
  Iomega ZIP drive, I've gotten to work with *every* PC
  configuration that I came across, since we used a ZIP drive to
  hold the customer's HD while we worked on it, for various video,
  sound, bios drivers, etc. etc. However, the Syquest drives,
  we've had nothing but trouble with. I don't know if it is the
  drivercomp.sys.tandys, or the hardware itself, but they have
  been very difficult to install - many times, we would be unable
  to do so. *(We never sold them, but often a customer would bring
  one they bought on sale elsewhere for us to install. *Much of
  the time, we would end up advising them to return the Syquest
  drive). The Iomega backup drives were equally simple to install.
  *And the Syquest were equally difficult to install :-/ I don't
  know why, but I would definately advice against the Syquest.
  Also, the ZIP is much more used and is more of a standard
  (probably because of its reliability). Just a few thoughts.
  -Kenneth