From [Knuxbine?s web site][1]:

> Knuxbine is a program which will allow macintosh users to easily
> combine their Sonic And Knuckles image with any other genesis image
> to make use of the Lock on Technology.
>
> Features:
>
>   * Sonic 3 and Knuckles Combine Works
>   * Sonic Special Stages/Sonic 1 3D Works
>   * Any other game Combine for special stage works
>   * Sonic 2 Combine Works!
>   * Easy to use
>   * Supports Balloon Help
>   * Can convert images between SMD and BIN
>   * Can Patch IPS Patches
>   * Can CREATE IPS Patches
>

Knuxbine is the only Macintosh program this uploader has found which
is capable of creating IPS patches (or binary patches of any kind) on
the classic Mac OS. Uploaded for posterity, this entry includes both
the 2.0 binary release as well as the ?unfinished source code to
Knuxbine 2.1,? in REALBasic format.

Compatibility
Architecture: PPC

Any PPC based Mac, with at least 4MB of available RAM

  [1]: https://projects.sappharad.com/old/sonicblur/knuxbine/index.html