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The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection [1]

['Juan F. Quintana', 'Lydia Becker Institute Of Immunology', 'Inflammation', 'University Of Manchester', 'United Kingdom', 'Division Of Immunology', 'Immunity To Infection', 'Health', 'Manchester Academic Health Science Centre', 'School Of Biodiversity']

Date: 2023-12

Citation: Quintana JF, Sinton MC, Chandrasegaran P, Kumar Dubey L, Ogunsola J, Al Samman M, et al. (2023) The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection. PLoS Biol 21(11): e3002389. https://doi.org/10.1371/journal.pbio.3002389

Academic Editor: Takeshi Tsubata, Tokyo Medical and Dental University Medical Research Institute, JAPAN

Received: August 14, 2023; Accepted: October 17, 2023; Published: November 20, 2023

Copyright: © 2023 Quintana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: The transcriptome data generated in this study have been deposited in the Gene Expression Omnibus (GSE229436). The processed transcript count data and cell metadata generated in this study, as well as the code for analysis, are available at Zenodo (DOI: 10.5281/zenodo.7814657 and https://zenodo.org/records/10018598). Additional data and files can also be sourced via Supplementary Tables. Code availability: The processed transcript count data and cell metadata generated in this study, as well as the code for analysis, are available at Zenodo (DOI: 10.5281/zenodo.7814657 and https://zenodo.org/records/10018598).

Funding: This work was funded by a Sir Henry Wellcome postdoctoral fellowship (221640/Z/20/Z to JFQ). AML is a Wellcome Trust Senior Research fellow (209511/Z/17/Z). PC and MCS are supported by a Wellcome Trust Senior Research fellowship (209511/Z/17/Z) awarded to AML. DB is funded by an MRC fellowship MR/V009052/1 and a Lister Institute Fellowship. NAM is supported by project Institute Strategic Programme Grant funding from the BBSRC (BBS/E/D/20002174 and BB/X010937/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

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[1] Url: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002389

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