BASIC INFORMATION
Habit forming? No
Prescription needed?
U.S.--Tablets: No
Liquid: Yes
Canada: Yes
Available as generic? Yes
Drug class: antihistamine, antiemetic.
USES
Prevents motion sickness.
DOSAGE AND USAGE INFORMATION
How to take:
Tablet--Swallow with liquid or food to lessen stomach
irritation. If you can't swallow whole, crumble tablet and
chew or take with liquid or food.
When to take:
30 minutes to 1 hour before traveling.
If you forget a dose:
Take as soon as you remember. Wait 4 hours for next dose.
What drug does:
Reduces sensitivity of nerve endings in inner ear, blocking
messages to brain's vomiting center.
Time lapse before drug works:
30 to 60 minutes.
Don't take with:
See interaction column and consult doctor.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
Symptoms What to do
____________________________________________________________________
Life-threatening:
None expected.
Common:
Drowsiness. Continue. Call doctor when
convenient.
Infrequent:
Headache, diarrhea or Continue. Call doctor when
constipation, fast convenient.
heartbeat.
Dry mouth, nose, throat. Continue. Tell doctor at next
visit.
Rare:
Rash, hives. Discontinue. Call doctor
right away.
Restlessness, excitement, Continue. Call doctor when
insomnia, blurred vision, convenient.
frequent and difficult
urination.
Appetite loss, nausea. Continue. Tell doctor at next
visit.
What to do:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
See emergency information.
WARNINGS AND PRECAUTIONS
Don't take if;
You are allergic to meclizine, buclizine or cyclizine.
You have taken MAO inhibitors in the past 2 weeks.
Before you start, consult your doctor:
If you have glaucoma.
If you have prostate enlargement.
If you have reacted badly to any antihistamine.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons, especially impaired urination
from enlarged prostate gland.
Pregnancy:
Studies inconclusive on harm to unborn child. animal studies
show fetal abnormalities. Decide with your doctor whether
drug benefits jsutify risk to unborn child.
Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing
until you finish medicine. Consult doctor for advice on
maintaining milk supply.
Infants and Children:
No problems expected.
Prolonged use:
No problems expected.
Skin and sunlight:
No problems expected.
Driving, piloting or hazardous work:
Don't fly aircraft. Don't drive until you learn how medicine
affects you. Don't work around dangerous machinery. Don't
climb ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and
reflexes, such as antihistamines, tranquilizers, sedatives,
pain medicine, narcotics and mind-altering drugs.
Discontinuing:
No problems expected.
Others:
No problems expected.
POSSIBLE INTERACTION WITH OTHER DRUGS
Generic Name or Drug class Combined Effect
____________________________________________________________________
Amphetamines May decrease drowsiness caused
by meclizine.
Anticholinergics Increased effect of both
drugs.
Antidepressants (tricyclic) Increased effect of both
drugs.
MAO inhibitors Increased meclizine effect.
Narcotics Increased effect of both
drugs.
Pain relievers Increased effect of both
drugs.
Sedatives Increased effect of both
drugs.
Sleep inducers Increased effect of both
drugs.
Tranquilizers Increased effect of both
drugs.
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
Interacts with Combined Effect
____________________________________________________________________
Alcohol Increased sedation. Avoid.
Beverages
Caffeine drinks May decrease drowsiness.
Cocaine None expected.
Foods None expected.
Marijuana Increased drowsiness, dry
mouth.
Tobacco None expected.
METOCLOPRAMIDE
BRAND NAMES
Emex Maxolon
Maxeran Reglan
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Antiemetic; dopaminergic blocker
USES
Releives nausea and vomiting caused by chemotherapy and drug
related postoperative factors.
Relieves symptoms of esophagitis.
DOSAGE AND USAGE INFORMATION
How to take:
Tablet or capsule--Swallow with liquid or food to lessen
stomach irritation.
When to take:
30 minutes before symptoms expected, up to 4 times a day.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than
2 hours, wait for next scheduled dose (don't double this
dose).
What drug does:
Prevents smooth muscle in stomach from relaxing.
Affects vomiting center in brain.
Time lapse before drug works:
30 to 60 minutes.
Don't take with:
See interaction column and consult doctor.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
Symptoms What to do
____________________________________________________________________
Life-threatening:
None expected.
Common:
Drowsiness, restlessness. Continue. Call doctor when
convenient.
Frequent:
Rash Continue. Call doctor when
convenient.
Infrequent:
Wheezing, shortness of Discontinue. Call doctor
breath. right away.
Dizziness; headache; Continue. Call doctor when
insomnia; tender, swollen convenient.
breasts; increased milk flow.
Rare:
Constipation, diarrhea, Continue. Call doctor when
nausea. convenient.
OVERDOSE
Symptoms:
Severe drowsiness, mental confusion, trembling, seizure, coma.
What to do:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If patient is unconscious and not breathing, give
mouth-to-mouth breathing. If there is no heartbeat, use
cardiac massage and mouth-to-mouth breathing (CPR). Don't try
to make patient vomit. If you can't get help quickly, take
patient to nearest emergency facility.
See emergency information.
WARNINGS AND PRECAUTIONS
Don't take if:
You are allergic to procaine, procainamide or metoclopramide.
Before you start, consult your doctor:
If you have Parkinson's disease.
If you have liver or kidney disease.
If you have epilepsy.
If you have bleeding from gastrointestinal tract or intestinal
obstruction.
If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons.
Pregnancy:
No proven harm to unborn child. Avoid if possible.
Breast-feeding:
Unknown effect.
Infants and children:
Adverse reactions more likely to occur than in adults.
Prolonged use:
Adverse reactions including muscle spasms and trembling hands
more likely to occur.
Skin and sunlight:
No problems expected.
Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't
climb ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and
reflexes, such as antihistamines, tranquilizers, sedatives,
pain medicine, narcotics and mind-altering drugs.
Discontinuing:
May be unnecessary to finish medicine. Follow doctor's
instructions.
Others:
No problems expected.
POSSIBLE INTERACTION WITH OTHER DRUGS
Generic Name or Drug Class Combined Effect
____________________________________________________________________
Acetaminophen Slow stomach emptying.
Bromocriptine Decreased bromocriptine
effect.
Central nervous system Excess sedation.
depressants: antidepressants,
antihistamines, muscle
relaxants, narcotics,
sedatives, sleeping pills,
tranquilizers.
Digitalis preparations Decreased absorption of
digitalis.
Levodopa Slow stomach emptying.
Phenothiazines Increased chance of muscle
spasm and trembling.
Tetracycline Slow stomach emptying.
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
Interacts with Combined Effect
____________________________________________________________________
Alcohol Excess sedation. Avoid
DOSAGE AND USAGE INFORMATION
How to take:
Tablet or capsule--Swallow with liquid or food to lessen
stomach irritation.
Suppositories--Remove wrapper and moisten suppository with
water. Gently insert into rectum, large end first.
Drops or liquid--Dilute dose in beverage.
When to take:
Nervous and mental disorders--Take at the same times each day.
Nausea and vomiting--Take as needed, no more often than every
4 hours.
If you forget a dose:
Nervous and mental disorders--Take up to 2 hours late. If
more than 2 hours, wait for next scheduled dose (don't double
this dose).
Nausea and vomiting--Take as soon as you remember. Wait 4
hours for next dose.
What drug does:
Suppresses brain's vomiting center.
Suppresses brain centers that control abnormal emotions and
behavior.
Time lapse before drug works:
Nausea and vomiting-- 1 hour or less.
Nervous and mental disorders--4-6 weeks.
Don't take with:
Antacid or medicine for diarrhea.
Non-prescription drug for cough, cold or allergy.
See Interaction column and consult doctor.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
Symptoms What to do
______________________________________________________________________
Life-threatening:
None expected.
Common:
Muscle spasms of face Discontinue. Seek emergency
and neck, unsteady gait. treatment.
Restlessness, tremor, Discontinue. Call doctor
drowsiness. right away.
Decreased sweating, dry Continue. Call doctor when
mouth, runny nose, convenient.
constipation.
Difficult urination, Continue. Call doctor when
diminished sex drive, convenient.
swollen breasts,
menstrual irregularities.
Rare:
Change in vision, sore Discontinue. Call doctor
throat, fever, jaundice. right away.
OVERDOSE
Symptoms:
Stupor, convulsions, coma.
What to do:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. then give first aid immediately.
See Emergency information section.
WARNINGS AND PRECAUTIONS
Don't take if:
You are allergic to any phentothiazine.
You have a blood or bone-marrow disease.
Before you start, consult your doctor:
If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
If you have asthma, emphysema or other lung disorder.
If you take non-prescription ulcer medicine, asthma medicine
or amphetamines.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons. More likely to develop
involuntary movement of jaws, lips, tongue, chewing. Report
this to your doctor immediately. Early treatment can help.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing
until you finish medicine. Consult doctor for advice on
maintaining milk supply.
Infants & children:
Don't give to children younger than 2.
Prolonged use:
May lead to tardive dyskinesia (involuntary movement of jaws,
lips, tongue, chewing).
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp. Skin may remain sensitive for 3 months after
discontinuing.
Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't
climb ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and
reflexes.
Discontinuing:
Nervous and mental disorders-Don't discontinue without
doctor's advice until you complete prescribed dose, even
though symptoms diminish or disappear.
Nausea and vomiting--May be unnecessary to finish medicine.
Follow doctor's instructions.
POSSIBLE INTERACTION WITH OTHER DRUGS
Generic Name or Drug Class Combined effect
______________________________________________________________________
Anticholinergics Increased anticholinergic
effect.
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Anitemetic
USES
Reduces nausea and vomiting.
DOSAGE AND USAGE INFORMATION
How to take:
Capsule--Swallow with liquid. If you can't swallow whole,
open capsule and take with liquid or food.
Suppositories--Remove wrapper and moisten suppository with
water. Gently insert larger end into rectum. Push well into
rectum with finger.
When to take:
When needed, no more often than label directs.
If you forget a dose:
Take when you remember. Wait as long as label directs for
next dose.
What drug does:
Possibly blocks nerve impulses to brain's vomiting centers.
Time lapse before drug works:
20 to 40 minutes.
Don't take with:
Non-prescription drugs or drugs in interaction column without
consulting doctor.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
Symptoms What to do
____________________________________________________________________
Life-threatening:
None expected.
Common:
None expected.
Infrequent:
Rash, blurred vision, Discontinue. Call doctor
low blood pressure. right away.
Dizziness, drowsiness, Continue. Call doctor when
headache, diarrhea, muscle convenient.
cramps, unusual tiredness.
Rare:
Seizures, tremor, Discontinue. Call doctor
depression, sore throat, right away.
fever, repeated vomiting,
back pain, jaundice.
OVERDOSE
Symptoms:
Confusion, convulsions, coma.
What to do:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
If patient is unconscious and not breathing, give
mouth-to-mouth breathing. If there is no heartbeat, use
cardiac massage and mouth-to-mouth breathing (CPR). Don't try
to make patient vomit. If you can't get help quickly, take
patient to nearest emergency facility.
See emergency information.
WARNINGS AND PRECAUTIONS
Don't take if:
You are allergic to trimethobenzamide.
You are allergic to local anesthetics and have suppository
form.
Before you start, consult your doctor:
If you have reacted badly to antihistamines.
Over age 60:
More susceptible to low blood pressure and sedative effects of
this drug.
Pregnancy:
No proven harm to unborn child. Avoid if possible.
Breast-feeding:
No proven problems. Avoid if possible.
Infants and Children:
Injectible form not recommended.
Avoid during viral infections. Drug may contribute to Reyes'
syndrome.
Prolonged use:
Damages blood-cell production of bone marrow.
Causes Parkinson-like symptoms of tremors, rigidity.
Skin and sunlight:
Possible sun sensitivity. Use caution.
Driving, piloting or hazardous work:
Use disqualifies you for piloting aircraft.
Don't drive until you learn how medicine affects you. Don't
work around dangerous machinery. Don't climb ladders or work
in high places. Danger increases if you drink alcohol or take
medicine affecting alertness and reflexes, such as
antihistamines, tranquilizers, sedatives, pain medicine,
narcotics and mind-altering drugs.
Discontinuing:
May be unnecessary to finish medicine. Follow doctor's
orders.
Other:
No problems expected.
POSSIBLE INTERACTION WITH OTHER DRUGS
Generic Name or Drug Class Combined Effect
____________________________________________________________________
Antidepressants Increased sedative effect.
Antihistamines Increased sedative effect.
Barbiturates Increased effect of both
drugs.
Belladonna Increased effect of both
drugs.
Cholinergics Increased effect of both
drugs.
Mind-altering drugs Increased effect of mind-
altering drug.
Narcotics Increased sedative effect.
Phenothiazines Increased effect of both
drugs.
Sedatives Increased sedative effect.
Sleep inducers Increased effect of sleep
inducer.
Tranquilizers Increased sedative effect.
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
Interacts with Combined effect
____________________________________________________________________
Alcohol Oversedation. Avoid.
Beverages None expected.
Cocaine None expected.
Foods None expected.
Marijuana Increased antinausea effect.
Tobacco None expected.
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