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Return to: OCREVUS (ocrelizumab) |
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#Post#: 2466-------------------------------------------------- |
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Fulminant hepatitis associated w/Echovirus 25 during Ocrevus tre |
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atment... |
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By: agate Date: April 8, 2019, 7:03 pm |
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I may be giving too much attention to rare, anecdotal instances |
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of adverse effects of the MS disease-modifying drugs, but here |
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is another one. This MS patient was taking Ocrevus but ended up |
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getting a liver transplant--and stopping the Ocrevus. This is |
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from JAMA Neurology (April 8, 2019), "Fulminant hepatitis |
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associated with Echovirus 25 during treatment with ocrelizumab |
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for multiple sclerosis": |
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http://bit.ly/2WXuNQ6 |
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This is from the discussion: |
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[quote] |
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[font=Guardian TextSans Web]Because ocrelizumab is a novel, |
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high-efficacy disease-modifying therapy for MS, it will probably |
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be extensively used. However, it may impair clearance of |
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enterovirus infections via B-cell depletion. Thus, in the case |
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of compatible symptoms, tests should be conducted for |
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enteroviruses. Given the bimodal clinical presentation (ie, the |
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patient had a severe rebound of liver enzyme levels after |
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initial improvement), patients receiving ocrelizumab with |
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enteroviral infection need close follow-up.[/font] |
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[/quote] |
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#Post#: 2587-------------------------------------------------- |
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Re: Fulminant hepatitis associated w/Echovirus 25 during Ocrevus |
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treatment... |
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By: ewizabeth Date: July 17, 2019, 10:54 am |
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I was required to get tested for all forms of hepatitis prior to |
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starting Ocrevus so now I know why. I was completely negative on |
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all of them. |
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