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Return to: Central Nervous system and Tissue Engineering |
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#Post#: 117-------------------------------------------------- |
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Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cel |
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By: SSamani Date: March 27, 2015, 4:29 pm |
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Injury in the central nervous system (CNS) is very serious and |
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may result in permanent disability of the patients, since it |
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causes neural cell death and tissue defects. There have been no |
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effective therapies so far, unfortunately. Many studies have |
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already shown that neural stem cells (NSC) can be used for |
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treatment of certain neurological diseases because they have the |
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intrinsic ability of self-renewal. However, the effect of NSC |
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grafting for neural restoration has been proven to be rather |
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limited because of low viability and undesired differentiation |
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in vivo. |
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It is critical therefore, that creation of a suitable |
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microenvironment or niche, composed of cells, blood vessels, |
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growth factors and the extracellular matrix (ECM), would play an |
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important role in regulating neurogenesis, survival and |
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regeneration of NSC. Thus, certain biomaterials used for neural |
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tissue engineering may offer a promising approach for creating |
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such a microenvironment, since they provide biological scaffolds |
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which can sustain the stem cells for transplantation and neural |
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regrowth in vivo. |
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Among those materials, the hyaluronic acid (HA)-based |
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biodegradable hydrogel has been proven to mimic brain ECM |
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effectively and to provide a good scaffold that is easily |
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modified with different useful molecules for promoting |
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regeneration |
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in the injured CNS. |
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[center]Download link |
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http://www.uplooder.net/cgi-bin/dl.cgi?key=58c419f9549e1d1b330faeb34ee630ba[/ce… |
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