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Return to: Cardiovascular Tissue Engineering |
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#Post#: 86-------------------------------------------------- |
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Cardiac repair using chitosan-hyaluronan/silk fibroin patches |
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By: SSamani Date: February 21, 2015, 1:36 pm |
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[font=verdana] |
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[center]Cardiac repair using chitosan-hyaluronan/silk fibroin |
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patches in a rat heart model with myocardial infarction |
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Carbohydrate Polymers 92 (2013) 591� 597[/center] |
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Abstract |
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The cardiac repair of myocardial infarction (MI) hearts of rats |
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using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac |
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patches was examined after eight weeks of implantation. Rats |
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with implantations of chitosan-HYA/SF patches (CHS group) |
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significantly (P <0.05) reduced the dilation of the inner |
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diameter of left ventricle (LV) (4.27�0.29 mm), increased wall |
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thickness of LV (1.5�0.13 mm) andimproved the fractional |
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shortening of LV of hearts (LVFS) (42.8�2.4%) compared with |
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those values of LVs of rats without implants (MI group) (e.g., |
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5.92�0.39 mm, 1.2�0.06 mm and 31.5�1.4%, respectively). |
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[font=verdana][size=small]Moreover, blood vessel-like structures |
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in MI regions of LVs in the CHS group were widely distributed |
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[/font][font=verdana]while none was found in the MI group. The |
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CHS group significantly improved the secretion of paracrine |
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[/font][font=verdana]factors, such as VEGF in the MI regions of |
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LVs (P<0.05, n=4), relative to that in the MI group. In |
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conclusion, [/font][font=verdana]chitosan-HYA/SF cardiac patches |
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are promising biomaterials for the cardiac repair of MI rat |
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hearts. |
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[/font] |
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[center]Download link |
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http://www.uplooder.net/cgi-bin/dl.cgi?key=971a59d8f942022b3aac6faf76af6452[/ce… |
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