 |
Return Create A Forum - Home |
 |
--------------------------------------------------------- |
|
Iranian Tissue Engineering |
 |
https://ite.createaforum.com |
|
--------------------------------------------------------- |
|
***************************************************** |
|
Return to: Peripheral Nervous system and Tissue Engineering |
|
***************************************************** |
|
#Post#: 71-------------------------------------------------- |
|
Schwann cell response on polypyrrole substrates |
|
By: SSamani Date: January 30, 2015, 11:44 pm |
|
--------------------------------------------------------- |
|
Schwann cell response on polypyrrole substrates upon electrical |
|
stimulation |
|
http://www.ncbi.nlm.nih.gov/pubmed/24512979 |
|
Forciniti L, Ybarra J 3rd, Zaman MH, Schmidt CE |
|
Current injury models suggest that Schwann cell (SC) migration |
|
and guidance are necessary for successful regeneration and |
|
synaptic reconnection after peripheral nerve injury. The ability |
|
of conducting polymers such as polypyrrole (PPy) to exhibit |
|
chemical, contact and electrical stimuli for cells has led to |
|
much interest in their use for neural conduits. Despite this |
|
interest, there has been very little research on the effect that |
|
electrical stimulation (ES) using PPy has on SC behavior. Here |
|
we investigate the mechanism by which SCs interact with PPy in |
|
the presence of an electric field. Additionally, we explored the |
|
effect that the adsorption of different serum proteins on PPy |
|
upon the application of an electric field has on SC migration. |
|
The results indicate an increase in average displacement of the |
|
SC with ES, resulting in a net anodic migration. Moreover, |
|
indirect effects of protein adsorption due to the oxidation of |
|
the film upon the application of ES were shown to have a larger |
|
effect on migration speed than on migration directionality. |
|
These results suggest that SC migration speed is governed by an |
|
integrin- or receptor-mediated mechanism, whereas SC migration |
|
directionality is governed by electrically mediated phenomena. |
|
These data will prove invaluable in optimizing conducting |
|
polymers for their different biomedical applications such as |
|
nerve repair. |
|
Acta Biomaterialia 10 (2014) 2423�2433 |
|
http://dx.doi.org/10.1016/j.actbio.2014.01.030 |
|
[center]Download link |
|
http://www.uplooder.net/cgi-bin/dl.cgi?key=b91d85eca5da9462d5611d31601c678d[/ce… |
|
***************************************************** |
