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Iranian Tissue Engineering |
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Return to: Cartilage Tissue Engineering |
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#Post#: 44-------------------------------------------------- |
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Electrospun nanofiber-based regeneration of cartilage |
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By: fmsbi Date: December 25, 2014, 6:33 pm |
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Application of biomaterials in combination with stem cells is a |
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novel tissue engineering approach to regenerate cartilage. The |
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objective of this study was to investigate the potential of |
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poly(vinyl alcohol)/polycaprolactone (PVA/PCL) nanofiber |
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scaffolds seeded with rabbit bone marrow-mesenchymal stem cell |
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(BM-MSC) for cartilage tissue engineering in vitro and in vivo. |
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We tested the biocompatibility and mechanical properties of |
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nanofibrous scaffolds using scanning electron microscope, MTT |
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assay, and tensile measurements. The capacity of MSC for |
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chondrogenic differentiation on scaffolds was examined using |
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reverse transcription-polymer chain reaction and immunostaining. |
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For in vivo assessments, PVA/PCL nanofiber scaffolds with or |
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without MSC were implanted into rabbit full-thickness cartilage |
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defects. To evaluate cartilage regeneration, semi-quantitative |
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grading and histological analysis were performed. Our results |
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showed that PVA/PCL scaffolds supported the proliferation and |
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chondrogenic differentiation of MSC in vitro. Moreover, the |
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animals treated with cell-seeded PVA/PCL scaffolds showed |
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improved healing of defects compared with untreated control and |
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those which received cell-free scaffolds. Our findings suggest |
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that PVA/PCL scaffolds incorporated with MSC can serve as a |
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suitable graft for articular cartilage reconstruction. � 2011 |
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Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A:467�467, |
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2011. |
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#Post#: 54-------------------------------------------------- |
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Re: Electrospun nanofiber-based regeneration of cartilage |
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By: SSamani Date: December 26, 2014, 12:35 pm |
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Hi |
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The article was shrunk to reduce size. |
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Yours |
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[center]Download link |
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http://www.uplooder.net/cgi-bin/dl.cgi?key=da4008e904c8a7b78d1ec573abb98ec9[/ce… |
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