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Iranian Tissue Engineering
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Return to: Peripheral Nervous system and Tissue Engineering
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#Post#: 33--------------------------------------------------
Comparative Study between Fibrin Scaffold and Autograft in Sciat
ic Nerve Repair:
By: nourani Date: December 17, 2014, 9:22 pm
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Background: Autograft is the golden standard approach in
reconstruction of peripheral nerve injuries. However, due to
limited accessibility to autograft and the high risk of neuroma
formation, an alternative repair method is the target of many
investigations. The objective of the present study was to
investigate the effect of using fibrin scaffold (FS) in
repairing injured sciatic nerve in rats.
Materials and Methods: Forty five male Wistar rats weighing
200-250g were randomly divided into three groups: control,
autograft (A) and fibrin scaffold (FS). The 5mm cut in right
sciatic nerve was repaired with autograft and FS in A and FS
groups. Animals were then assessed by behavioral and EMG tests
in one, three and five weeks following the induced injury.
Results were then compared in three groups using one way ANOVA
Results: The obtained data in the first, 3rd and the 5th weeks
after the recovery showed no significant difference between
experimental groups, but there was a significant difference
between experimental groups and the control group. The mean
functional index of the sciatic nerve was in parallel in both
experimental groups throughout the five weeks of follow-up
period. The mean motor response delay had a similar trend and
was not significantly different in experimental groups. So was
the amplitude of the mean motor action potential.
Conclusion: The presented data are in favor of the notion that
the fibrin scaffold could potentially be considered as an
alternative approach for autograft transplants in peripheral
nerve injuries.
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