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#Post#: 11--------------------------------------------------
What is POIS? (from Wikipedia)
By: truthaboutpois Date: April 5, 2015, 10:43 am
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Post orgasmic illness syndrome (POIS) is a rare condition
characterized by debilitating symptoms following orgasm that
last for a few hours to several days. The phenomenon was first
described in 2002.
Symptoms
Symptoms usually appear within half an hour of orgasm and
resolve after a few days. The person experiences mental
symptoms, physical symptoms, or both. Common mental symptoms
include cognitive dysfunction, intense discomfort, irritability,
anxiety, craving for relief, susceptibility to nervous system
stresses (e.g. common cold), depressed mood, and difficulty
communicating, remembering words, reading and retaining
information, concentrating, and socialising. Physical symptoms
include severe fatigue, mild to severe headache, and flu-like
and allergy-like symptoms, such as sneezing, itchy eyes, nasal
irritation, and muscle pain. Affected individuals may also
experience intense warmth or cold.
Diagnosis
Waldinger says this condition is prone to being erroneously
ascribed to psychological factors or hypochondria. In a 2010
British Medical Journal case study, Dexter links a form of
coital headache with POIS, and references a science forum in
which thousands of sufferers (a number which is rapidly growing)
have detailed their condition. Dexter's patient was found to
have low progesterone.
Management
Affected individuals typically avoid sexual activity, especially
orgasm, or schedule it for times when they can rest and recover
for several days afterwards.
Two people have been treated using hyposensitation techniques
for semen allergies. One person, who had been symptomatic for 27
years, was treated norethisterone, half an hour before, and in
the minutes just after orgasm.
Pathophysiology
Most recently, in early 2011, Professor Waldinger and
collaborators further characterized POIS, proposed a specific
immunological mechanism, and empirically supported their
hypothesis on 45 Dutch Caucasian males. This study concluded
that both Type-1 and Type-4 allergy to male's own semen
contribute to symptoms of the illness.
Dexter speculates that POIS could be caused by a lack of
progesterone, a powerful neurosteroid, or a defect in
neurosteroid precursor synthesis. In the latter case, the same
treatment may not be effective for different sufferers.
Different sufferers may have different missing precursors,
ultimately leading to a deficiency of the same particular
neurosteroid, causing similar symptoms.
An array of more subtle, lingering symptoms after orgasm, which
would not constitute POIS, may contribute to habituation between
mates. They may show up as restlessness, irritability, increased
sexual frustration, apathy, sluggishness, neediness,
dissatisfaction with a mate, or weepiness over the days or weeks
after intense sexual stimulation. Such phenomena may be part of
human mating physiology itself. Habituation to a mate can drive
the search for novel mates (the Coolidge effect).
One researcher suggests that the symptoms may be produced by an
autoimmune reaction against any of various hormones or other
substances secreted during and after sex. Another suggests that
chemical imbalances in the brain may cause the symptoms.
It is difficult to demonstrate a causal relationship based on
patient reports.
Sexual activity for the first time may set the stage for an
associated asthmatic attack or may aggravate pre-existing
asthma. Intense emotional stimuli during sexual intercourse can
lead to autonomic imbalance with parasympathetic over
reactivity, thereby causing release of mast cell mediators that
can provoke postcoital asthma and/or rhinitis in these
patients�.
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